Our Mission

COMBINEDBrain is devoted to speeding the path to clinical treatments for people with rare genetic neurological disorders by pooling effort, studies, and data.

Our Structure

COMBINEDBrain is a nonprofit consortium led by patient advocacy foundations and supported by clinicians, researchers, and pharmaceutical partners working to develop treatments for rare neurological disorders. We connect more than 130 rare neurological disorder communities across key sectors—patient advocacy, academic researchers and clinicians, and industry—through shared research infrastructure.

Through structured initiatives such as multi-stakeholder roundtables and cross-disease research programs, COMBINEDBrain brings these sectors together in ways that do not typically occur in traditional research models. This enables direct collaboration, shared insights, and coordinated research across disorders.

COMBINEDBrain also develops and operates shared research infrastructure—including biobanking, data integration platforms, and expert access programs—that support study execution and accelerate therapeutic development. Partners gain access to a broader network of collaborators, datasets, and research opportunities, while contributing to the collective through shared data, expertise, and resources.

Project FIND-OUT (Fast Infant Neurogenetic Diagnosis via Outpatient Testing) is a national initiative designed to accelerate the diagnosis of rare genetic neurodevelopmental disorders in infants. The project expands access to early genetic testing and clinical evaluation to identify underlying genetic conditions sooner, helping families obtain answers earlier and enabling more timely clinical care and research participation. By reducing the time to diagnosis, Project FIND-OUT also aims to improve opportunities for early intervention and participation in emerging therapeutic research.

For more information, please contact ProjectFINDOUT@combinedbrain.org or visit the FINDOUT website.